BSWG KOL lecture series, L08

Event Date:



Title: BOIN - a Novel Platform for Designing Early Phase Clinical Trials
Speaker: Ying Yuan, Department of Biostatistics, University of Texas MD Anderson Cancer Center

Bayesian optimal interval (BOIN) designs belong to a new class of early phase trial designs known as model-assisted designs, which utilize statistical models for efficient decision making, but their dose transition rules can be pre-tabulated as the 3+3 design. The BOIN design can be implemented in a simple way as the 3+3 design, but yields superior performance comparable to model-based designs. In this talk, we will introduce a suite of BOIN designs that can be used to find the maximum tolerated dose (MTD) for single-agent trials, drug-combination trials, as well as trials with late-onset toxicity, under a unified framework. The freely available software at will be demonstrated using trial examples.

Skype link:
Join by phone: +1 (317) 277-1498 or +1 (855) 545-5910
Meeting ID: 1407450


Starting Time:

12:00 pm

Ending Time:

2:00 pm